NOTES:
- All selections were for the Entry Draft, known as the Amateur Draft prior to 1979, unless otherwise indicated.
- An asterisk (*) indicates the player was drafted prior to attending RPI.
| YEAR | PLAYER | TEAM | ROUND/OVERALL PICK |
| 1973 | Don Cutts | New York Islanders | 7/97 |
| 1977 | Steve Stoyanovich | New York Islanders | 4/69 |
| 1978 | Larry Landon | Montreal Canadiens | 8/137 |
| 1978 | Kevin Constantine | Montreal Canadiens | 9/154 |
| 1978 | Don Boyd | St. Louis Blues | 12/191 |
| 1980 | Mike McPhee | Montreal Canadiens | 6/124 |
| 1981 | Marty Dallman | Los Angeles Kings | 4/81 |
| 1981 | Eric Magnuson | New York Rangers | 6/114 |
| 1981 | Steve Kudebeh * | Minnesota North Stars | 10/202 |
| 1982 | Mike Dark * | Montreal Canadiens | 6/124 |
| 1982 | John Tiano * | New York Islanders | 7/147 |
| 1982 | John Shumski | St. Louis Blues | 10/197 |
| 1983 | Daren Puppa * | Buffalo Sabres | 4/74 |
| 1983 | Ken Hammond | Los Angeles Kings | 8/147 |
| 1983 | Brian Jopling * | Philadelphia Flyers | 11/221 |
| 1984 | Tom Hussey * | New York Rangers | 7/140 |
| 1984 | Bill Kopecky * | Boston Bruins | 11/227 |
| 1985 | Steve Moore * | Boston Bruins | 5/94 |
| 1985 | Rob Schena * | Detroit Red Wings | 9/176 |
| 1985 | Maurice Mansi | Montreal Canadiens | 10/198 |
| 1985 | John Haley * | Edmonton Oilers | 12/251 |
| 1986 | Tony Hejna * | St. Louis Blues | 3/52 |
| 1986 | Brian Ferreira * | Boston Bruins | 8/160 |
| 1986 | Matt Lanza * | Edmonton Oilers | 10/210 |
| 1987 | Clint Thomas * | New York Rangers | 7/136 |
| 1987 | Tim Roberts * | Buffalo Sabres | 8/153 |
| 1987 | Gavin Armstrong | Edmonton Oilers | 9/189 |
| 1987 | Ryan Kummu | Washington Capitals | 12/246 |
| 1988 | Joe Juneau | Boston Bruins | 4/81 |
| 1988 | Cam Brauer | Edmonton Oilers | 4/82 |
| 1988 | Todd Hilditch * | Washington Capitals | 8/162 |
| 1989 | Allen Kummu * | Philadelphia Flyers | 10/201 |
| 1990 | Bruce Coles | Montreal Canadiens | 1/23 (Supplemental Draft) |
| 1991 | Brad Layzell | Montreal Canadiens | 5/100 |
| 1991 | Adam Bartell * | Quebec Nordiques | 9/178 |
| 1991 | Neil Little | Philadelphia Flyers | 11/226 |
| 1991 | Xavier Majic | Vancouver Canucks | 12/249 |
| 1992 | Wayne Clarke | Toronto Maple Leafs | 9/197 |
| 1993 | Kyle Ferguson * | Toronto Maple Leafs | 10/253 |
| 1994 | Bryan Masotta * | Ottawa Senators | 4/81 |
| 1994 | Doug Battaglia * | Detroit Red Wings | 5/127 |
| 1994 | Chris Aldous * | Montreal Canadiens | 10/252 |
| 1995 | Mark Murphy * | Toronto Maple Leafs | 8/197 |
| 1997 | Pete Gardiner | Chicago Blackhawks | 5/120 |
| 1998 | Jim Henkel * | Los Angeles Kings | 8/217 |
| 1999 | Matt Murley | Pittsburgh Penguins | 2/51 |
| 1999 | Andrew McPherson | Pittsburgh Penguins | 9/261 |
| 2000 | Marc Cavosie | Minnesota Wild | 4/99 |
| 2000 | Nathan Marsters * | Los Angeles Kings | 5/165 |
| 2000 | Danny Eberly | New York Rangers | 8/238 |
| 2001 | Francois Senez | Detroit Red Wings | 9/288 |
| 2004 | Christian Jensen * | San Jose Sharks | 9/289 |
| 2007 | Allen York * | Columbus Blue Jackets | 6/168 |
| 2008 | Jeff Foss | Nashville Predators | 6/166 |
| 2008 | Mike Bergin * | Dallas Stars | 7/209 |
| 2009 | Brandon Pirri * | Chicago Blackhawks | 2/59 |
| 2009 | Jerry D'Amigo * | Toronto Maple Leafs | 6/158 |
| 2011 | Pat Koudys | Washington Capitals | 5/147 |
| 2011 | Jason Kasdorf * | Winnipeg Jets | 6/156 |
| 2012 | Lou Nanne * | Minnesota Wild | 7/188 |
| 2014 | Mike Prapavessis * | Dallas Stars | 4/105 |
| 2014 | Chase Perry * | Detroit Red Wings | 5/136 |
| 2016 | Todd Burgess * | Ottawa Senators | 4/103 |
| 2017 | Will Reilly | Pittsburgh Penguins | 7/217 |
| 2018 | Simon Kjellberg * | New York Rangers | 6/163 |
| 2023 | Sutter Muzzatti | Nashville Predators | 5/143 |